Biomedical Research Journal

REVIEW ARTICLE
Year
: 2021  |  Volume : 8  |  Issue : 1  |  Page : 9--13

Is three-parent IVF the answer to preventing mitochondrial defects?


Shloka Shetty 
 Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS (Deemed-to-be University), Mumbai, Maharashtra, India

Correspondence Address:
Ms. Shloka Shetty
Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS (Deemed-to-be University), Bhaidas Sabhagriha Building, Bhaktivedanta Swami Marg, Vile Parle (W), Mumbai - 400 056, Maharashtra
India

Mitochondrial DNA (mtDNA), as its name implies, is an embodiment of the mitochondrial genetic information that constitutes about 1% of the mammalian genome. It fills a vital niche in tracing matrilineality; the mtDNA is inherited solely from the mother and plays a crucial role in genealogical research. Even a single mutation in the mtDNA can have debilitating and life-altering consequences. Mothers carrying mtDNA mutations will inevitably pass it on to the future generation. Three-parent In vitro fertilization (IVF), a breakthrough technique, shows promising potential to prevent mothers with mtDNA defects from passing it on to their future generation, while also maintaining the genetic link to their posterity. In this review, I delve into the intricacies of this technique, compare and analyze the difference between maternal spindle transfer and pronuclear transfer, discuss the prospective therapeutic effects, and highlight the ethical concerns surrounding this procedure. Considering the various challenges and ethics of this contentious technique, the paper seeks to answer the rousing question – Is three-parent IVF the answer to preventing mitochondrial defects?


How to cite this article:
Shetty S. Is three-parent IVF the answer to preventing mitochondrial defects?.Biomed Res J 2021;8:9-13


How to cite this URL:
Shetty S. Is three-parent IVF the answer to preventing mitochondrial defects?. Biomed Res J [serial online] 2021 [cited 2021 Dec 2 ];8:9-13
Available from: https://www.brjnmims.org/article.asp?issn=2349-3666;year=2021;volume=8;issue=1;spage=9;epage=13;aulast=Shetty;type=0