RESEARCH ARTICLE
Year : 2014 | Volume
: 1 | Issue : 1 | Page : 71--85
Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells
Sunil Gangadharan1, Anjali A Karande2
1 Johns Hopkins University School of Medicine, Department of Oncology, Orleans St Baltimore, USA
2 Department of Biochemistry, Indian Institute of Science, Bangalore, India
Correspondence Address:
Anjali A Karande
Department of Biochemistry, Indian Institute of Science, Malleswaram, Bangalore 560012
India
Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons and bind to receptors on gonadotrope cells of the pituitary gland, which then synthesize and release luteinizing hormone and follicle-stimulating hormone that regulate gonadal development. The presence of GnRH receptors and the effects of synthetic analogs of GnRH at extrapituitary sites is less clear. Several reports suggest that GnRH/analogues through cognate receptors may regulate mitogenic responses in cancer cells in an autocrine or paracrine manner. However, the inherent intracellular signaling pathways triggered are unknown. Using a highly specific antibody to human GnRH receptor we show that T47D breast cancer cells express GnRH receptors on their surface and that a GnRH analogue Cetrorelix inhibits proliferation of these cells, possibly via inhibition of processes that trigger cAMP formation.
How to cite this article:
Gangadharan S, Karande AA. Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells.Biomed Res J 2014;1:71-85
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How to cite this URL:
Gangadharan S, Karande AA. Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells. Biomed Res J [serial online] 2014 [cited 2023 Sep 25 ];1:71-85
Available from: https://www.brjnmims.org/article.asp?issn=2349-3666;year=2014;volume=1;issue=1;spage=71;epage=85;aulast=Gangadharan;type=0 |
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