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Year : 2014  |  Volume : 1  |  Issue : 1  |  Page : 71-85

Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells

1 Johns Hopkins University School of Medicine, Department of Oncology, Orleans St Baltimore, USA
2 Department of Biochemistry, Indian Institute of Science, Bangalore, India

Correspondence Address:
Anjali A Karande
Department of Biochemistry, Indian Institute of Science, Malleswaram, Bangalore 560012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2349-3666.240662

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Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons and bind to receptors on gonadotrope cells of the pituitary gland, which then synthesize and release luteinizing hormone and follicle-stimulating hormone that regulate gonadal development. The presence of GnRH receptors and the effects of synthetic analogs of GnRH at extrapituitary sites is less clear. Several reports suggest that GnRH/analogues through cognate receptors may regulate mitogenic responses in cancer cells in an autocrine or paracrine manner. However, the inherent intracellular signaling pathways triggered are unknown. Using a highly specific antibody to human GnRH receptor we show that T47D breast cancer cells express GnRH receptors on their surface and that a GnRH analogue Cetrorelix inhibits proliferation of these cells, possibly via inhibition of processes that trigger cAMP formation.

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